Four women in the isolated frontier territory go mad, and it is up to the unlikely combination of homesteader Mary Bee Cuddy and ne'er-do-well Briggs to escort them east to safety.
Single woman and pioneer Mary Bee Cuddy saves the life of claim jumper George Briggs in return for his help in getting three women who have gone insane from Nebraska to Iowa.
A dying gunman returns to his friend for medical care in his last days, but becomes involved with a widow and her son, eventually dying with honor in a final gunfight.